![]() The impairment of brain function caused by neonatal exposure to sevoflurane is not specific to the learning deficit. 11 The primary cause of these learning deficits in the adults is not fully understood, which hinders identification of the underlying pathophysiology. 1–10 Furthermore, long after the anesthetic exposure, learning deficits are manifested later in adulthood 1–5 even though a significant increase in neuronal apoptosis is no longer evident. ACCUMULATING evidence indicates that exposure to general anesthetics at clinically effective concentrations induces widespread increases in neuronal apoptosis in the developing brain of a variety of animals ranging from rodents to rhesus monkeys.
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